Enterovirus 2C Protein Drug Design, Assay Development, and Drug Resistance Studies.

Accounts of chemical research · 2026-11-01 · 期刊论文

In this Account, we describe our efforts to establish enteroviral 2C as a tractable target for antiviral drug discovery by integrating medicinal chemistry, molecular pharmacology, resistance profiling, structural modeling, and assay development. Rather than relying solely on conventional phenotypic high-throughput screening, our initial studies focused on the rational optimization of reported 2C inhibitors identified…

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Li K, Demssie HA, Fan G 等

本文摘自《每日前沿研究简报 · 2026-11-06》「化学信息 / 药物发现」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。