Engineering ATP import in yeast uncovers a synthetic route to extend cellular lifespan

eLife · 2026-11-11 · 期刊论文

Mitochondrial dysfunction and declining ATP production are common features of aging, yet whether ATP availability itself directly regulates cellular lifespan is unclear. However, the causal relationship between cellular ATP homeostasis and aging has not been established. Here, we developed a synthetic system to manipulate intracellular ATP independently of endogenous energy production by expressing a plasma membrane-…

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本文摘自《每日前沿研究简报 · 2026-11-12》「eLife」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。