IER3-N-cadherin axis contributes to apoptosis resistance in dermal fibroblasts under profibrotic conditions

bioRxiv 预印本 · 2026-11-03 · 预印本

Background: Persistent activation and resistance to apoptosis of dermal fibroblasts contribute to pathological skin fibrosis. Immediate early response 3 (IER3) is a stress-responsive protein involved in cell survival, but its role in cutaneous fibrosis remains unclear. We investigated the functional significance of IER3 in dermal fibroblasts and its potential contribution to fibrosis. Methods: IER3 expression was exa…

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Ichimura, R., Nakajima, H., Sugimori, A. 等

本文摘自《每日前沿研究简报 · 2026-11-05》「生物信息 / 组学（单细胞·差异表达）」。本内容仅用于研究信息整理与科普交流，不构成医疗建议。